https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:39601 Wed 29 Mar 2023 13:54:42 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30082 versus 25% of acute ischaemic stroke patients, p = 0.0016). In both hospitals, reasons for exclusion from IV-tPA treatment were intracerebral haemorrhage, mild symptoms, and stroke mimic. Patients with baseline National Institutes of Health Stroke Scale score =5 were more likely to be excluded from IV-tPA in the Japanese hospital. Of patients treated with IV-tPA, the door-to-needle time (median, 63 versus 54 minutes, p = 0.0355) and imaging-to-needle time (34 versus 27 minutes, p = 0.0220) were longer in the Australian hospital. Through international benchmarking using cohorts captured under ASC, significant differences were noted in rates of IV-tPA treatment and workflow speed. This variation highlights opportunity to improve and areas to focus targeted practice improvement strategies.]]> Wed 19 Jan 2022 15:15:36 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:47147 post hoc cost-effectiveness analysis was undertaken. Part A: patient-level cost and health effect data (Multidimensional Fatigue Inventory (MFI) scores) were derived from the MIDAS trial and analysis undertaken from a health-system perspective. Part B: a secondary analysis simulated the societal impact of modafinil therapy in terms of national productivity costs. Results: Part A: Mean cost of modafinil treatment was AUD$3.60/day/patient for a minimally clinically important change (10 points) in total MFI fatigue score, i.e., AUD$0.36/day/unit change in fatigue score per patient. For the base case scenario, the ICER of using modafinil (versus placebo) was AUD$131.73 ($90.17 - 248.15, for minimum and maximum costs, respectively). Part B: The potential productivity cost-savings to society were calculated as nearly AUD$467 million over 1 year, and up to $383,471,991,248 over 10 years, from the widespread use of modafinil treatment in the Australian population of working-age stroke-survivors, representing a significant societal benefit. Conclusions: Modafinil is a highly cost-effective treatment for post-stroke fatigue, offering significant productivity gains and potential cost-savings to society from the widespread use of modafinil treatment in the Australian population of working-age stroke-survivors.]]> Wed 14 Dec 2022 15:27:36 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:39768 Wed 13 Mar 2024 08:58:17 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52454 Wed 11 Oct 2023 15:03:16 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:16986 Wed 11 Apr 2018 12:42:10 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:13751 Wed 11 Apr 2018 12:40:01 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:13689 Wed 11 Apr 2018 12:02:09 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:1820 =65 years of age. Case-fatality rates showed similar trends with a 1- to 2-month lag compared with attack rates. Conclusions: There is an increase in stroke attack rates and case-fatality rate from summer to winter in the Hunter Region, Australia. These trends are similar to those found in the Northern Hemisphere.]]> Wed 11 Apr 2018 09:35:35 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:35216 .05). Conclusion: White matter changes after stroke may be localized rather than a global phenomenon.]]> Wed 06 Apr 2022 13:57:07 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:38904 P < 0.001), with higher rates of atrial fibrillation, hypertension and diabetes mellitus. Stroke complicating cardiac catheterisation was associated with an increased risk of readmission, with a significantly higher hazard of readmission for stroke noted. Despite minimal functional impairment based on modified Rankin score, stroke was associated with a significant risk of early and cumulative mortality. Stroke incidence remained stable over the study period despite changes in procedural practice. Conclusions: The incidence and functional severity of stroke remains low despite evolving procedural practice with a stable incidence over time despite changes in procedural practice; however, post-procedural stroke confirms an increased mortality hazard.]]> Wed 02 Mar 2022 12:28:28 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:41993 6 s (sensitivity, 88%; specificity, 92%). The computed tomographic perfusion collateral index, defined by the ratio of delay time >6 s/delay time >2 s volume, showed a significant correlation with dynamic computed tomographic angiography collateral scores (correlation coefficient, 0.62; P<0.001), with an optimal cut point of 31.8% in predicting good collateral status (sensitivity of 83% and specificity of 86%). When predicting good clinical outcome, the delay time collateral index showed a similar predictive power to dynamic computed tomographic angiography collaterals (area under the curve, 0.78 [0.67–0.83] and 0.77 [0.69–0.84], respectively; P<0.001). Conclusions—Computed tomographic perfusion can accurately quantify collateral flow after acute ischemic stroke.]]> Tue 16 Aug 2022 16:37:23 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:31178 Tue 11 Sep 2018 12:07:51 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:44306 Tue 11 Oct 2022 15:59:20 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:42877 Tue 06 Sep 2022 10:34:20 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:36192 Thu 27 Feb 2020 09:35:33 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52638 Thu 19 Oct 2023 15:12:05 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:33105 Thu 17 Mar 2022 14:41:28 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:38922 Thu 16 Nov 2023 12:20:26 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:33725 Thu 13 Jan 2022 10:30:08 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30014 14 second R2 = 0.372, P = 0.011). Patients with WMHP also had larger acute infarcts and increased infarct growth compared to those without WMHP (mean 28 mL vs. 13 mL P < 0.001). Conclusion: White matter hypoperfusion remote to the acutely ischemic region on CTP is a marker of small vessel disease and was associated with increased HT, larger acute infarct cores, and greater infarct growth.]]> Thu 13 Jan 2022 10:29:30 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:34103 Thu 07 Feb 2019 14:26:26 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:33112 Thu 04 Nov 2021 10:38:21 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:13753 Sat 24 Mar 2018 10:39:17 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:8108 Sat 24 Mar 2018 08:40:00 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:15325 Sat 24 Mar 2018 08:26:35 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:14102 Sat 24 Mar 2018 08:24:01 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:17430 2 s was the most accurate computed tomography perfusion threshold in predicting the extent of critically hypoperfused tissue with both receiver operating curve analysis (area under curve 0.86), and the volumetric validation (mean difference between computed tomography perfusion and 24-h diffusion-weighted imaging lesions = 2 cm², 95% confidence interval 0.5–3.2 cm²). Cerebral blood flow <40% (of contralateral) within the relative delay time >2 s perfusion lesion was the most accurate computed tomography perfusion threshold at defining infarct core with both receiver operating characteristic analysis (area under curve = 0.85) and the volumetric validation. Using these thresholds, the extent of computed tomography perfusion mismatch tissue (the volume of ‘at-risk’ tissue between the critically hypoperfused and core thresholds) salvaged from infarction correlated with clinical improvement at 24 h (R² = 0.59, P = 0.04) and 90 days (R² = 0.42, P = 0.02). Patients with larger baseline computed tomography perfusion infarct core volume (>25 ml) also had poorer recovery at Day 90 (P = 0.039). Computed tomography perfusion can accurately identify critically hypoperfused tissue that progresses to infarction without early reperfusion, and the computed tomography perfusion cerebral blood flow infarct core closely predicts the final volume of infarcted tissue in patients who do reperfuse. The computed tomography perfusion infarct core and at-risk measures identified are also strong predictors of clinical outcome.]]> Sat 24 Mar 2018 08:01:40 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:18959 Sat 24 Mar 2018 07:58:54 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:17731 Sat 24 Mar 2018 07:57:44 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:16870 Sat 24 Mar 2018 07:54:47 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:27843 Sat 24 Mar 2018 07:41:15 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:27631 Sat 24 Mar 2018 07:34:04 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:4665 Sat 24 Mar 2018 07:19:33 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:32690 Mon 23 Sep 2019 13:22:20 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:18704 Mon 20 Jul 2015 17:48:19 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:46980 Mon 12 Dec 2022 17:01:27 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:46977 50-year-old were more often hospitalized in the COVID-19 period (P = 0.042). SARS-CoV-2 PCR test was done in 49.3% out of all COVID-19 period patients, which were positive in 6.5%. Modified Rankin Scale (mRS) score ≥3 at three-month follow-up was associated with age (P = 0.015) and malignancy (P = 0.014) in pre-COVID period; and was associated with age (P = 0.025), altered mental status on admission time (P<0.001), malignancy (P = 0.041) and COVID-19 infection (P = 0.008) in COVID-19 period. Conclusion: Since there was a more dismal outcome in COVID-19 associated CVST, a high index of suspicion for CVST among COVID-19 positive is recommended.]]> Mon 12 Dec 2022 17:01:24 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:51943 Fri 22 Sep 2023 16:57:08 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:47058 Fri 19 Apr 2024 14:52:35 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:41805 Fri 12 Aug 2022 12:31:27 AEST ]]>